Coding and non-coding RNA interactions reveal immune-related pathways in peripheral blood mononuclear cells derived from patients with proliferative vitreoretinopathy

Abstract Background Peripheral immune response has been revealed to play a critical role in proliferative vitreoretinopathy (PVR). However, the reliable immune-related factors that are acting as prognostic indicators or therapeutic targets for PVR remain explore further. Methods In current study, we applied whole-transcriptome sequencing profile peripheral blood mononuclear cells from patients and also analyzed lncRNA-mRNA interactions pathways might mediate immunopathology resultant retinal damage PVR. Gene ontology (GO), Kyoto Encyclopedia of Genes Genomes (KEGG) pathway enrichment analyses Ingenuity Pathway Analysis (IPA) were employed classify function these differentially expressed genes. Results Compared controls, there 319 genes upregulated, 191 downregulated patients. GO, KEGG well IPA showed upregulated significantly enriched infection-relate terms. Immune-related gene NFKBIA , CXCL2 CXCL8 detected hub-genes co-expression network, while lncRNAs such AC007032.1 AC037198.2 AL929472.2 SLED1 highly co-expressed with them. analysis putative targeted pathways. Conclusion Our study highlights transformation genes/pathways by comparing validates several lncRNAs, which serving potential diagnostic markers